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This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity). It also includes information pertinent to the sequence(s), including length and molecular weight.

This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).

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Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.

of multiple genes (paralogs).

ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/S0927519303800372URL: https://www.sciencedirect.com/science/article/pii/B0122272102001801URL: https://www.sciencedirect.com/science/article/pii/B9780120781607500196URL: https://www.sciencedirect.com/science/article/pii/B9780124160248000143URL: https://www.sciencedirect.com/science/article/pii/B9780323523561000025URL: https://www.sciencedirect.com/science/article/pii/S0074769608621464URL: https://www.sciencedirect.com/science/article/pii/B9780080468846013105URL: https://www.sciencedirect.com/science/article/pii/B9780323523561000311URL: https://www.sciencedirect.com/science/article/pii/B978012382026600018XURL: https://www.sciencedirect.com/science/article/pii/B9781455728565000455Planar Lipid Bilayers (BLMs) and Their ApplicationsAguilar-Bryan & Bryan, 1999; Aguilar-Bryan et al., 1998; Mannhold, 2004; Seino, 1999Dorschner, Brekardin, Uhde, Schwanstecher, & Schwanstecher, 1999Acevedo et al., 2006; Lybaert, Leleux, Meuris, & Lebrun, 2010; Lybaert et al., 2008Clinical Arrhythmology and Electrophysiology (Third Edition)Ventricular Arrhythmias in Inherited ChannelopathiesClinical Arrhythmology and Electrophysiology (Third Edition)Organization and Electrophysiology of Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastrointestinal TractPhysiology of the Gastrointestinal Tract (Fifth Edition)The Molecular Pathophysiology of Atrial FibrillationCardiac Electrophysiology: From Cell to Bedside (Sixth Edition)ScienceDirect ® is a registered trademark of Elsevier B.V.

Inwardly rectifying potassium channels, as the name implies, allow more KMembers of the Kir6.0 subfamily associate with the sulfonylurea receptor, a member of the ABC family, and form KTwo-pore channels are a newly identified family of potassium channels.

This section provides general information on the entry.

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Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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Potassium Channels : Inward rectifier (I ir or I K1) Contributes to late phase 3 repolarization; maintains phase 4 negative potential : Transient outward (I to) Contributes to phase 1 of non-pacemaker cardiac action potentials: Delayed rectifiers (I Kr and I Ks)

This section provides information on the location and the topology of the mature protein in the cell.

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TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization.

Inward Rectifier Potassium Channel Assays. It is useful for tracking sequence updates.

Strongly rectifying Kir channels exhibit a very steep voltage dependence resulting in silencing of their activity at depolarized membrane voltages.

Inferred from Biological aspect of Ancestor

Members of the inward rectifier family of potassium (Kir) channels regulate a myriad of physiological processes, including cardiac function, pain processing and opioid action, learning and memory, insulin secretion and epithelial solute transport [1,2].Some inward rectifiers occupy unique physiological niches that raise intriguing questions about their potential as therapeutic targets.

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have the same checksum value, the likelihood that this would happen

This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.

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This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.

Examples: P92958, Q8TDN4, O14734

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Heart, skeletal muscle, and several different brain regions including the hippocampus.

This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.

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Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium

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